Elevated SFXN2 limits mitochondrial autophagy and increases iron-mediated energy production to promote multiple myeloma cell proliferation
Abstract Human sideroflexin 2 (SFXN2) belongs to the SFXN protein family, which is a mitochondrial outer membrane protein involved in mitochondrial iron metabolism.Mitochondria are indispensable for cellular energy production and iron metabolism.However, it remains elusive how SFXN2 modulates mitochondrial homeostasis and cellular iron metabolism i