ELEVATED SFXN2 LIMITS MITOCHONDRIAL AUTOPHAGY AND INCREASES IRON-MEDIATED ENERGY PRODUCTION TO PROMOTE MULTIPLE MYELOMA CELL PROLIFERATION

Elevated SFXN2 limits mitochondrial autophagy and increases iron-mediated energy production to promote multiple myeloma cell proliferation

Abstract Human sideroflexin 2 (SFXN2) belongs to the SFXN protein family, which is a mitochondrial outer membrane protein involved in mitochondrial iron metabolism.Mitochondria are indispensable for cellular energy production and iron metabolism.However, it remains elusive how SFXN2 modulates mitochondrial homeostasis and cellular iron metabolism i

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Evaluation of a creatinine clearance correction equation based on body fat mass in older Japanese patients with diabetes

BackgroundThe estimation of creatinine clearance (CCr) in older adult patients with diabetes is subject to deviations from the results of actual measurements Wood Plaque With Wooden Stand because of changes in body composition.In the present study, we aimed to create a correction for the equation used for the estimation of CCr in older adult Asian

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Outcomes and predictors of response to fractionated radiotherapy as primary treatment for intracranial meningiomas

Background: Surgery is the primary treatment for most meningiomas.However, primary fractionated radiotherapy (fRT) remains an option for patients with larger meningiomas in challenging anatomic locations or patients at prohibitively high surgical risk.Outcome prediction for these Wood Plaque With Wooden Stand patients is uncertain and cannot be gui

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